Diagnostic features of multiple organic system disorders associated with COVID-19 in a child of primary school age.

The advent of the COVID-19, specialists are increasingly encountering previously unknown pathological conditions in their practice. For some time, we have believed, that COVID-19 in children is most often mild and asymptomatic. However, with the passage of time and. the accumulation, of the experience, it became obvious that the new infectious disease it will be quite severe in children. Differential diagnosis of multiple organ disorders in children during the COVID-19 pandemic should, be primary carried out with the Multisystem. Inflammatory Syndrome in Children, associated, with COVID-19 (MIS-C), as well as Long-COVID-19. According to published, data, the manifestations of these conditions are due to frequent lesions of the gastrointestinal tract (60-100%), cardiovascular (80%), nervous (29-58%) and respiratory (21-65%) systems. At present, there is no exact idea of these pathological conditions, the criteria for their diagnosis and. the tactics of managing children, not only at the stage of diagnosis, but also at the stage of observation. The authors present a diagnostically complex clinical case describing the development of multiple organ damage in a 7-year-old. child, after contact with a mother who was sick with COVID-19. The data on the course features, the results of the examination and. the difficulties of differential diagnosis of this case with other diseases with a similar clinic are summarized.Copyright © 2022 Authors. All rights reserved.

Diagnostic features of multiple organic system disorders associated with COVID-19 in a child of primary school age.

The advent of the COVID-19, specialists are increasingly encountering previously unknown pathological conditions in their practice. For some time, we have believed, that COVID-19 in children is most often mild and asymptomatic. However, with the passage of time and. the accumulation, of the experience, it became obvious that the new infectious disease it will be quite severe in children. Differential diagnosis of multiple organ disorders in children during the COVID-19 pandemic should, be primary carried out with the Multisystem. Inflammatory Syndrome in Children, associated, with COVID-19 (MIS-C), as well as Long-COVID-19. According to published, data, the manifestations of these conditions are due to frequent lesions of the gastrointestinal tract (60-100%), cardiovascular (80%), nervous (29-58%) and respiratory (21-65%) systems. At present, there is no exact idea of these pathological conditions, the criteria for their diagnosis and. the tactics of managing children, not only at the stage of diagnosis, but also at the stage of observation. The authors present a diagnostically complex clinical case describing the development of multiple organ damage in a 7-year-old. child, after contact with a mother who was sick with COVID-19. The data on the course features, the results of the examination and. the difficulties of differential diagnosis of this case with other diseases with a similar clinic are summarized.Copyright © 2022 Authors. All rights reserved.

Diagnostic features of multiple organic system disorders associated with COVID-19 in a child of primary school age.

The advent of the COVID-19, specialists are increasingly encountering previously unknown pathological conditions in their practice. For some time, we have believed, that COVID-19 in children is most often mild and asymptomatic. However, with the passage of time and. the accumulation, of the experience, it became obvious that the new infectious disease it will be quite severe in children. Differential diagnosis of multiple organ disorders in children during the COVID-19 pandemic should, be primary carried out with the Multisystem. Inflammatory Syndrome in Children, associated, with COVID-19 (MIS-C), as well as Long-COVID-19. According to published, data, the manifestations of these conditions are due to frequent lesions of the gastrointestinal tract (60-100%), cardiovascular (80%), nervous (29-58%) and respiratory (21-65%) systems. At present, there is no exact idea of these pathological conditions, the criteria for their diagnosis and. the tactics of managing children, not only at the stage of diagnosis, but also at the stage of observation. The authors present a diagnostically complex clinical case describing the development of multiple organ damage in a 7-year-old. child, after contact with a mother who was sick with COVID-19. The data on the course features, the results of the examination and. the difficulties of differential diagnosis of this case with other diseases with a similar clinic are summarized.Copyright © 2022 Authors. All rights reserved.

Tuberculosis under conditions of novel coronavirus infection

Tuberculosis (TB) remains an important medical and social problem up to today. In recent years, great strides have been made in the fight against tuberculosis infection (TI) in reducing TB morbidity and mortality, especially in the Russian Federation. Emergence of new COVID-19 infection in the world has led to the need for long-term isolation of the population, on the one hand, and the need to resort to personal protective equipment, on the other. The spread of COVID-19 may have an impact on the increase in TB morbidity, despite the decrease in the incidence rate, which is related to objective difficulties in detecting TB and complexity of the structure of clinical manifestations of the disease against the background of coronavirus infection and severe complications after COVID-19. The use of immunosuppressive therapy in the treatment of COVID-19 may cause immunosuppression, which will affect the results of TI immunodiagnostics using skin tests. At the same time, IGRA tests can be useful in these conditions, since they are of great diagnostic value. Equally important is the reduction of patient visits to treatment facilities in the context of a pandemic or a high incidence of COVID-19.

Immunotherapy in the treatment of covid-19

The high mortality rate in COVID-19 can be explained by the development of a hyperinflammatory syndrome, characterized by a cytokine storm and extensive thrombus formation. The main direction for preventing the development of hyperinflammatory syndrome and reducing mortality from COVID-19 is immune therapy, however, the data on the efficacy and criteria for prescribing immune drugs is very heterogeneous. The purpose of this review is to analyze the results of clinical trials on the use of various types of immune therapy and possible criteria for its prescription. Analysis of literature data showed that the most effective among the existing variants of immune therapy were monoclonal antibodies to IL-6, the use of donor plasma in the early stages of treatment. Janus kinase inhibitors, intravenous immunoglobulin improved the clinical characteristics of patients, but did not affect the mortality rate. An analysis of possible predictor-markers of the development of a cytokine storm revealed an increase in the number of neutrophils > 11 × 103/ml, a decrease in the number of lymphocytes > 1000 × 103/ml, an increase in the level of IL-6 > 24 pg/ml, LDH > 300 IU/L, D-dimer > 1000 ng/ml, and CRP > 10 mg/dL as the most informative and accessible in clinical practice at the moment.

Features of tuberculosis diagnosis in the CoVID-19

2020 began with the most significant pandemic COVID-19 in the history of this century. The epidemiology indicators are growing every day. The spread of COVID-19 may affect an increase in the incidence of tuberculosis, despite a decrease in the incidence rate that is associated with objective difficulties in detecting tuberculosis against the background of COVID-19 and severe complications after the new coronavirus infection. Tuberculosis is one of the infectious diseases, and the problem of its spread continues to be relevant throughout the World. The effect of the SARS-CoV-2 virus can cause certain difficulties in the diagnosis and treatment of tuberculosis infection. The possibility of concomitant these infectious diseases can affect the clinical course of tuberculosis, an influence on mortality of the disease, but at the same time, there is a decrease in the number of cases that is not objective. The authors analyzed the currently published data on detecting tuberculosis in the conditions of the COVID-19 problem and presented difficulties in the diagnosis of COVID-19 and TB concomitant diseases with a description in the clinical case. © 2021 Interregional public organization Association of infectious disease specialists of Saint-Petersburg and Leningrad region (IPO AIDSSPbR). All rights reserved.

New coronaviral infection: Features of clinical course, capabilities of diagnostics, treatment and prevention in adults and children

First cases of new coronaviral infection were reported in Wuhan, Hubei Province, China in December 2019. The infection had caused the death of more than 100,000 people worldwide by the beginning of April 2020. This review analysed the characteristics of the infection course in adults and children, as well as capabilities of diagnostics, treatment and prevention of COVID-19. It is possible to allocate groups of high risk of development of severe forms of disease (elderly people, people with latent tuberculosis infection, adult patients with severe comorbidity) according to the published data. Currently there is limited epidemiological data on the prevalence, morbidity and mortality of COVID-19 in the child population. However, it is already possible to conclude that 90% of cases in children population have mild, moderate and asymptomatic course of the disease. Treatment of patients with COVID-19 is limited due to the lack of means for etiotropic therapy and the possibility of using of only symptomatic therapy. There are no vaccines for COVID-19 prevention.